Substances at a glance
| Substance | Withdrawal picture | Main danger |
|---|---|---|
| Alcohol | Tremor, sweat, anxiety | Seizure / delirium risk |
| Opioids | Aches, cramps, diarrhoea | Overdose after tolerance drops |
| Benzodiazepines | Anxiety, tremor, insomnia | Seizure risk — do not stop abruptly |
| Stimulants | Crash, fatigue, low mood | Chest pain, psychosis, suicide risk |
| Cannabis | Irritable, poor sleep | Usually supportive care |
| GHB / GBL | Rapid agitation / confusion | Can become severe very quickly |
1 · Assess first
- Substance, route, amount, frequency and last use
- Past severe withdrawal, seizure, delirium or overdose
- Other sedatives, medicines, medical and mental health risks
- Observations, mental state, pregnancy, supports and safe setting
2 · Red flags — escalate
- Reduced consciousness, slow breathing or overdose
- Seizure, delirium or severe / rapidly worsening withdrawal
- Chest pain, severe agitation, psychosis or suicidal intent
- Unstable observations, pregnancy complications or unsafe setting
3 · Withdrawal: A‑P‑M‑T‑C
Assess risk → Place safely → Monitor → Treat to plan → Continue care. Alcohol, benzodiazepine and GHB withdrawal may be dangerous. Withdrawal is one stage, not the whole treatment plan.
4 · OAT made simple
- Methadone — full agonist; strong craving/withdrawal control; accumulation and sedation risk
- Sublingual buprenorphine — partial agonist; lower overdose risk; may precipitate withdrawal if started too early
- LAIB — weekly/monthly injection; never invent catch-up dosing
5 · Missed OAT doses
| Missed | Action |
|---|---|
| 1–3 days | Dosing clinician reviews; usual dose may be given if safe; notify prescriber |
| 4–5 days | Review plus prescriber contact; reduced restart may be authorised |
| More than 5 days | Prescriber review and re-induction |
| Frequent individual misses | Clinical review — tolerance and exposure may be unpredictable |
6 · Treatment options
Harm reduction and naloxone · OAT · planned withdrawal · counselling · relapse-prevention medicines · rehabilitation · peer, family and social support.
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